Placental Deficiency During Maternal SARS-CoV-2 infection
Aim of this study conducted by our researchers was to evaluate the risk of vertical transmission of SARS-CoV-2 and placental passage of anti-Spike antibodies placental structures.
– Anti-SARS-CoV-2 Spike antibodies can cross to neonates at birth. SARS-CoV-2 infection may cause maternal and fetal unfavourable outcomes.
– The concentrations of total anti-SARS-CoV-2 Spike antibodies were higher in pregnant women with moderate to severe/critical disease.
– The maternal total anti-SARS-CoV-2 Spike levels were correlated with those of neonatal levels.
– The rate of placental abnormalities is high in the mothers with severe disease, and those with positive anti-SARS-CoV-2 IgM.
– The maternally derived anti-SARS-CoV-2 Spike antibody can transmit to neonates born to infected mothers regardless of gestational age.
– Our results indicated that the disease severity is associated with ischemic placental pathology which may result in adverse pregnancy outcomes.
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